|
Custom services
As independent experts, our aim is to help you achieve your targets on time and on budget. We can currently offer the following custom chemistry services.
- Analogue and Hit to Lead (H2L) library synthesis
- Library synthesis for patent exemplification
- Reference compounds or literature compounds
- Intermediate and building block synthesis
- Synthesis of cytotoxic agents
- Synthesis of labeled intermediates or drugs
- Asymmetric synthesis
- Synthesis of unnatural amino acids, nucleosides and nucleotides
- Steroid synthesis
Drug discovery
We have been identifying appropriate CROs and providing medicinal chemistry experience and leadership we can provide innovative, timely and cost effective Hit-to-Lead and Lead Optimization resource in the following areas.
- Design and synthesis of focussed libraries
- Management of hit-to-lead and lead optimization programs using out-sourced chemistry resource
In addition to providing chemistry services, we help clients access other disciplines required to identify pre-clinical development candidates (for example, pharmacokinetic, in vitro toxicology and formulation services). With our extensive network of contacts we are able to call upon experts in a wide range of fields to help you achieve success.
Process chemistry and synthesis
CROs in India, which can offer the following Development services:
- Analytical R&D
- Process R&D and
- Kilo-lab scale cGMP synthesis with GLP support
Analytical R&D
Analytical method development and validation for pre-clinical and clinical studies. Method development can be carried out from scratch or to fine tune existing methods to develop identification assays, identify impurities, or characterize (cGMP) material.
Process R&D
Process optimization in order to eliminate synthetic steps or expensive starting materials, develop proprietary processes or identify kilo-scale routes suitable for manufacturing.
CGMP synthesis
India has the largest number of FDA approved manufacturing sites outside the US. Where required, kilo-scale synthesis can be carried out by cGMP compliant laboratories adhering to FDA regulations and ICH guidelines, many with recent FDA inspections.
Patent and due diligence analysis
We offer a range of Patent and Due Diligence services based on our industry experience and understanding of Medicinal Chemistry and Drug Discovery. Our goal is to support (not supplant) your third party intellectual property advisors or patent agents.
Patent Analysis
we assists clients with the following areas of intellectual property protection:
- Prior art examination
- Patent drafting
- Claim analysis
- Strategic advice on securing robust chemistry-based intellectual property
Using our medicinal chemistry expertise we can help clients file robust and meaningful patents to protect their small molecule intellectual property. By combining medicinal chemistry skills with cost effective laboratory chemistry we can strengthen patents by designing (and synthesizing) focussed libraries aimed at improving patent exemplification.
Due Diligence Analysis
we provides clients with independent due diligence on small molecule in-licensing opportunities to evaluate
- Intellectual property protection
- SAR data
- Pharmacokinetic / pharmacodynamic relationships
- The potential for further optimization and scope for the development of orally bioavailable drugs
We can write due diligence reports and provide sound, unbiased scientific analysis to complement your internal resource. Our due diligence services range from examination of NCE intellectual property to detailed analysis of the medicinal chemistry component of potential in-licensing opportunities.
|
